We moved to new offices a month ago and I have settled in to the new route to work. Nico's nursery was a bit out of the way when I was working in the city centre, but now it is about a mile in the wrong direction.
But this is not so bad, since I have decided on a -Ofun route  which is almost entirely on cycle paths and very quiet roads, and the main on-road section has good cycle lanes (at least by UK standards). There is lots of park land, a bit of open country, and it goes through the world heritage site in the city centre :-) And it's fairly easy to stop off on the way if I need to get supplies.
 optimize for fun!
My route to work on gmap-pedometer
I don't have to wrangle children on the way home, so I take the direct route past the Institute of Astronomy and Greenwich House (where Rachel previously worked and where the Royal Greenwich Observatory was wound down).
My route home on gmap-pedometer
So far it has been pleasantly free of the adrenaline spikes I get from seeing murderous and/or suicidally stupid behaviour. Much better than going along Chesterton Lane and Madingley Road!