We moved to new offices a month ago and I have settled in to the new route to work. Nico's nursery was a bit out of the way when I was working in the city centre, but now it is about a mile in the wrong direction.
But this is not so bad, since I have decided on a -Ofun route  which is almost entirely on cycle paths and very quiet roads, and the main on-road section has good cycle lanes (at least by UK standards). There is lots of park land, a bit of open country, and it goes through the world heritage site in the city centre :-) And it's fairly easy to stop off on the way if I need to get supplies.
 optimize for fun!
I don't have to wrangle children on the way home, so I take the direct route past the Institute of Astronomy and Greenwich House (where Rachel previously worked and where the Royal Greenwich Observatory was wound down).
So far it has been pleasantly free of the adrenaline spikes I get from seeing murderous and/or suicidally stupid behaviour. Much better than going along Chesterton Lane and Madingley Road!